Stiff-person syndrome

Muscular rigidity often fluctuates ie grows worse and then improves and usually occurs along with the muscle spasms. Stiff-person syndrome SPS also known as stiff-man syndrome SMS 1 is a rare neurologic disorder of unclear cause characterized by progressive rigidity and stiffness.


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Muscle spasms can be so violent they can dislocate joints and even break bones.

. Stiff person syndrome SPS is a very rare disease affecting only one or two people per million. Stiff person syndrome SPS is a neurological disease with autoimmune features. Symptoms include muscle spasms and rigidity.

Muscle rigidity sporadic muscle spasms and chronic muscle pain characterize SPS. Autoimmune disorders including diabetes thyroiditis vitiligo and pernicious anemia. Symptoms may include extreme muscle stiffness rigidity and painful spasms in the trunk and limbs severely impairing mobility.

Symptoms include stiffening in the torso and limbs along with episodes of severe muscle spasms. SPS is strongly correlated with autoimmune diseases and it is usual to find high titers of antibodies against acid decarboxylase GAD65. Stiff person syndrome SPS is a rare progressive syndrome that affects the nervous system specifically the brain and spinal cord.

Stiff person syndrome SPS is a rare autoimmune neurological disorder. Stiff-person syndrome SPS is a rare acquired neurological disorder characterized by progressive muscle stiffness rigidity and repeated episodes of painful muscle spasms. Certain cancers including breast lung kidney thyroid colon and Hodgkins lymphoma.

Stiff-person syndrome SPS is a rare and disabling central nervous system disorder with no satisfactory treatment. Spasms can generate enough force to fracture bone. But more people are affected than reported due to misdiagnoses.

Abnormal postures often hunched over and stiffened are characteristic of. Stiff-person syndrome SPS is a rare neurological disorder with features of an autoimmune disease. Symptoms include muscle spasms hyper-rigidity debilitating pain and chronic anxiety.

SPS is labeled as a rare disease. The stiffness primarily affects the truncal muscles and is superimposed by spasms resulting in postural deformities. SPS is characterized by fluctuating muscle rigidity in the trunk and limbs and a heightened sensitivity to stimuli such as noise touch and emotional distress which can set off muscle spasms.

Medications and immunotherapy maybe prescribed with aqua occupational and physical therapy. Learn more about the treatment and outlook for the condition here. Why Choose Johns Hopkins.

Stiff person syndrome is more likely seen in people with certain types of diseases including. It causes progressive muscle stiffness and painful spasms that can be triggered by a variety of things including sudden movement cold temperature or unexpected loud noises. An autoimmune and neurological disorder that causes rigidity and spasms in the trunk and limbs.


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